New Nasal Treatment Could Add Years Before Alzheimer's Progression
Scientists at Texas A&M have developed a revolutionary nasal spray delivery system that could delay Alzheimer's progression by up to 15 years by using stem cell-derived vesicles to reduce inflammation and protein buildup in the brain.
Texas A&M Scientists Develop Nasal Spray That Could Delay Alzheimer's by Years
Texas A&M University researchers have developed a nasal spray that could significantly slow the progression of Alzheimer's disease, potentially delaying mental decline by 10-15 years.
Key Research Findings
- The spray uses nanosized extracellular vesicles derived from stem cells
- Treatment targets multiple brain regions through non-invasive delivery
- Reduces brain inflammation and protein buildup linked to Alzheimer's
- Works by delivering therapeutic molecules directly to brain cells
How It Works
The nasal spray contains tiny vesicles that can:
- Quickly penetrate the brain
- Target different types of brain cells
- Protect brain cells
- Change gene expression to slow mental decline
Current Status
The research team has:
- Completed successful animal trials
- Shown the treatment reduces brain inflammation
- Demonstrated reduction in abnormal protein buildup
- Started work on medicines for human trials
Looking Ahead
While promising, public availability remains several years away. The next steps include:
- Producing medicines from nervous system stem cells
- Conducting human clinical trials
- Testing safety and effectiveness in patients
Source: Newsweek article by Sean Duke, Nov 12, 2024 https://www.newsweek.com/nasal-spray-could-delay-alzheimers-years-1984450
https://isevjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12519
